Natural history of chronic hepatitis B REVEALed. | reveal hbv
ChronichepatitisBisaworldwidepublichealthchallenge.KnowledgeofnaturalhistoryofchronichepatitisBisimportantforthemanagementofthedisease.Acommunity-basedprospectivecohortstudywascarriedouttoevaluatetheriskpredictorsofprogressionofchronichepatitisBinTaiwan.Atotalof23,820participantswereenrolledin1991-1992fromseventownshipsinTaiwan.TheirserumsampleswerecollectedatstudyentryandtestedforhepatitisBsurfaceantigen(HBsAg)andeantigen(HBeAg),antibodiesagainsthepatitisCvirus(anti-HCV),alanineaminotransfe...
Chronic hepatitis B is a worldwide public health challenge. Knowledge of natural history of chronic hepatitis B is important for the management of the disease. A community-based prospective cohort study was carried out to evaluate the risk predictors of progression of chronic hepatitis B in Taiwan. A total of 23,820 participants were enrolled in 1991-1992 from seven townships in Taiwan. Their serum samples were collected at study entry and tested for hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), antibodies against hepatitis C virus (anti-HCV), alanine aminotransferase (ALT), and α-fetoprotein (AFP). A subcohort of 3653 male and female participants who were seropositive for HBsAg and seronegative for anti-HCV was included in the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) study. Newly developed cases of cirrhosis and hepatocellular carcinoma (HCC) were a...