Natural history of chronic hepatitis B | reveal hbv
DownloadthePDFhere[1]LiverInternationalEarlyView Articlefirstpublishedonline:17APR2012 "TheRiskEvaluationofViralLoadElevationandAssociatedLiver Disease/Cancer-HepatitisBVirus(REVEAL-HBV)StudywasinitiatedtoaddressthisveryquestionwithparticularfocusontheroleofquantitativeHBVDNAlevelsinpredictingliverdiseaseprogression." "DatafromtheREVEAL-HBVstudyhavehelpedestablishanHBVviralloadparadigminthenaturalhistoryofchronichepatitisB[8,35,36,37].SerumHBVDNAlevelwasidentifiedasthemostimportantriskpredi...
Download the PDF here[1]Liver International Early View Article first published online: 17 APR 2012 "The Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) Study was initiated to address this very question with particular focus on the role of quantitative HBV DNA levels in predicting liver disease progression." "Data from the REVEAL-HBV study have helped establish an HBV viral load paradigm in the natural history of chronic hepatitis B [8, 35, 36, 37]. Serum HBV DNA level was identified as the most important risk predictor for progressing to end-stage liver disease outcomes [17, 18, 38]. A fairly significant finding was the biological gradient of disease progression risk across the serum HBV DNA levels from a single measurement; in the case of progression to HCC, this risk gradient was found to be even more striking among chronic HBV carriers who were HBeAg-seronegative with normal ALT le...