Risk of Hepatocellular Carcinoma Across a Biological ... | reveal hbv
Context SerumhepatitisBvirus(HBV)DNAlevelisamarkerofviralreplicationandefficacyofantiviraltreatmentinindividualswithchronichepatitisB.Objective ToevaluatetherelationshipbetweenserumHBVDNAlevelandriskofhepatocellularcarcinoma.Design,Setting,andParticipants Prospectivecohortstudyof3653participants(aged30-65years),whowereseropositiveforthehepatitisBsurfaceantigenandseronegativeforantibodiesagainstthehepatitisCvirus,recruitedtoacommunity-basedcancerscreeningprograminTaiwanbetween1991and1992.Main...
Context Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B.
Objective To evaluate the relationship between serum HBV DNA level and risk of hepatocellular carcinoma.
Design, Setting, and Participants Prospective cohort study of 3653 participants (aged 30-65 years), who were seropositive for the hepatitis B surface antigen and seronegative for antibodies against the hepatitis C virus, recruited to a community-based cancer screening program in Taiwan between 1991 and 1992.
Main Outcome Measure Incidence of hepatocellular carcinoma during follow-up examination and by data linkage with the national cancer registry and the death certification systems.
Results There were 164 incident cases of hepatocellular carcinoma and 346 deaths during a mean follow-up of 11.4 years and 41 779 person-years of follow-up. The incidence of he...