Osteocyte apoptosis | quiescent osteocyte
AbstractVitalosteocyteshavebeenwellknowntofunctionasanimportantorchestratorinthepreservationofrobustnessandfidelityoftheboneremodelingprocess.Nevertheless,somekeypathologicalfactors,suchassexsteroiddeficiencyandexcessglucocorticoids,andsoon,areimplicatedininducingabulkofapoptoticosteocytes,subsequentlyresultinginresorption-relatedboneloss.Asmuch,osteocyteapoptosis,underhomeostaticconditions,isinanoptimalstateofbalancetightlycontrolledbypro-andanti-apoptoticmechanismpathways.Importantly,there...
AbstractVital osteocytes have been well known to function as an important orchestrator in the preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some key pathological factors, such as sex steroid deficiency and excess glucocorticoids, and so on, are implicated in inducing a bulk of apoptotic osteocytes, subsequently resulting in resorption-related bone loss. As much, osteocyte apoptosis, under homeostatic conditions, is in an optimal state of balance tightly controlled by pro- and anti-apoptotic mechanism pathways. Importantly, there exist many essential signaling proteins in the process of osteocyte apoptosis, which has a crucial role in maintaining a homeostatic environment. While increasing in vitro and in vivo studies have established, in part, key signaling pathways and cross-talk mechanism on osteocyte apoptosis, intrinsic and complex mechanism underlying osteocyte apoptosis occurs in various states of patholo...