Role of Chondrocytes in Cartilage Formation | articular cartilage function
JDevBiol.Authormanuscript;availableinPMC2016Jun22.Publishedinfinaleditedformas:PMCID:PMC4916494NIHMSID:NIHMS794939BiologicalSciences,UniversityofDelaware,Newark,DE19716,USA*Authortowhomcorrespondenceshouldbeaddressed;ude.ledu@ehonajna[1];Tel.:+1-302-831-2959;Fax:+1-302-831-2281.ThepublishersfinaleditedversionofthisarticleisavailableatJDevBiol[2]SeeotherarticlesinPMCthatcite[3]thepublishedarticle.AbstractArticularcartilage(AC)coversthediarthrodialjointsandisresponsibleforthemechanicaldistribu...
J Dev Biol. Author manuscript; available in PMC 2016 Jun 22.
Published in final edited form as:
PMCID: PMC4916494
NIHMSID: NIHMS794939
Biological Sciences, University of Delaware, Newark, DE 19716, USA
*Author to whom correspondence should be addressed; ude.ledu@ehonajna[1]; Tel.: +1-302-831-2959; Fax: +1-302-831-2281. The publishers final edited version of this article is available at J Dev Biol[2]See other articles in PMC that cite[3] the published article.AbstractArticular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical distribution of loads across the joints. The majority of its structure and function is controlled by chondrocytes that regulate Extracellular Matrix (ECM) turnover and maintain tissue homeostasis. Imbalance in their function leads to degenerative diseases like Osteoarthritis (OA). OA is characterized by cartilage degradation, osteophyte formation and stiffening of joi...